Current Issue : July - September Volume : 2017 Issue Number : 3 Articles : 6 Articles
The main objective of this work was to study the physicochemical characterization of naturally available Fagopyrum esculentum (buckwheat) seed gum as a novel biodegradable pharmaceutical excipient. As buckwheat seed gum was being explored for the first time for its pharmaceutical application, physicochemical, rheological and stability studies with preservatives were conducted. The rheological results showed that buckwheat gum dispersion possesses dilatancy. It was observed that the buckwheat seed gum followed a non-Newtonian flow, which was confirmed by the existence of a nonlinear relationship between apparent viscosity and shear rate. The DSC profile showed endothermic comparatively sharp peak found at 279.81°C which was close to melting point of buckwheat gum. Thus the study confirmed the successful characterization of buckwheat seed gum. It showed that it can be used as an excipient for pharmaceutical products because of its abundant availability, reliability, efficiency, ecofriendly and economical features. And it would be a good substitute for synthetic polymers....
Theformulation of a potential delivery system based on liposomes (Lips) formulated fromsoy lecithin (SL) for paclitaxel (PTX) was\nachieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized\nfor their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated\nthat PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of 131 �± 30.5 nm. Besides, PTX was\nefficiently encapsulated in Lips, 94.5 �± 3.2% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX.\nMore importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the\nincorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX. As a result, development of Lips using\nSL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy....
The successful topical therapy of onychomycosis depends on effective drug release and penetration into nail, which can be achieved\nby using an adequately developed delivery system. This study evaluated and compared effect of film-forming polymers Eudragit\nRL100, Eudragit RS100, and ethyl cellulose on naftifine hydrochloride release fromexperimental nail lacquer formulations. Quality\nof formulations was evaluated by determining drying time and water resistance. Interactions between active pharmaceutical\ningredient and excipients were investigated using microcalorimetry and FT-IR. Optimization of nail lacquer formulations was\nperformed by naftifine hydrochloride release testing. Release of naftifine hydrochloride increased with increasing concentration of\nEudragit RL100. Plasticizer triacetin affected the release of naftifine hydrochloride, when Eudragit RS100 polymer was used. Ethyl\ncellulose polymer was determined to be not applicable for naftifine hydrochloride nail lacquer formulations. Two compositions of\nnail lacquers were optimized and could be used in further development of transungual delivery systems....
The main challenges facing efforts to prevent the transmission of human immunodeficiency\nvirus (HIV) are the lack of access to sexual education services and sexual violence against young\nwomen and girls. Vaginal formulations for the prevention of sexually transmitted infections\nare currently gaining importance in drug development. Vaginal mucoadhesive tablets can be\ndeveloped by including natural polymers that have good binding capacity with mucosal tissues,\nsuch as chitosan or guar gum, semisynthetic polymers such as hydroxypropylmethyl cellulose,\nor synthetic polymers such as EudragitÃ?® RS. This paper assesses the potential of chitosan for the\ndevelopment of sustained-release vaginal tablets of Tenofovir and compares it with different polymers.\nThe parameters assessed were the permanence time of the bioadhesionââ?¬â?determined ex vivo using\nbovine vaginal mucosa as substrateââ?¬â?the drug release profiles from the formulation to the medium\n(simulated vaginal fluid), and swelling profiles in the same medium. Chitosan can be said to allow\nthe manufacture of tablets that remain adhered to the vaginal mucosa and release the drug in a\nsustained way, with low toxicity and moderate swelling that ensures the comfort of the patient and\nmay be useful for the prevention of sexual transmission of HIV....
The aim of the study was to investigate the effects of the loading factors, i.e., the initial\ndrug loading concentration and the ratio of the drug to carriers, on the in vitro pharmaceutical\nperformance of drug-loaded mesoporous systems. Ibuprofen (IBU) was used as a model drug, and\ntwo non-ordered mesoporous materials of commercial silica SyloidÃ?® 244FP (S244FP) and NeusilinÃ?®\nUS2 (NS2) were selected in the study. The IBU-loaded mesoporous samples were prepared by a\nsolvent immersion method with a rotary evaporation drying technique and characterized by polarized\nlight microscopy (PLM), Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction\n(XRPD) and differential scanning calorimetry (DSC). Dissolution experiments were performed in\nsimulated gastric media at 37 ââ??¦C under non-sink conditions. The concentration of IBU in solution\nwas determined by HPLC. The study showed that the dissolution rate of IBU can be improved\nsignificantly using the mesoporous S224FP carriers due to the conversion of crystalline IBU into\nthe amorphous form. Both of the loading factors affected the IBU dissolution kinetics. Due to the\nmolecular interaction between the IBU and NS2 carriers, the loading factors had little effects on\nthe drug release kinetics with incomplete drug desorption recovery and insignificant dissolution\nenhancement. Care and extensive evaluation must therefore be taken when mesoporous materials\nare chosen as carrier delivery systems....
Chitosan is a versatile polysaccharide of biological origin. Due to the biocompatible\nand biodegradable nature of chitosan, it is intensively utilized in biomedical applications in\nscaffold engineering as an absorption enhancer, and for bioactive and controlled drug release.\nIn cancer therapy, chitosan has multifaceted applications, such as assisting in gene delivery and\nchemotherapeutic delivery, and as an immunoadjuvant for vaccines. The present review highlights\nthe recent applications of chitosan and chitosan derivatives in cancer therapy....
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